Journal article

Predicting Depression Onset in Young People Based on Clinical, Cognitive, Environmental, and Neurobiological Data

Yara J Toenders, Akhil Kottaram, Richard Dinga, Christopher G Davey, Tobias Banaschewski, Arun LW Bokde, Erin Burke Quinlan, Sylvane Desrivieres, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rudiger Bruehl, Jean-Luc Martinot, Marie-Laure Paillere Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Herve Lemaitre, Tomas Paus Show all

BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING | ELSEVIER | Published : 2022

Abstract

Background: Adolescent onset of depression is associated with long-lasting negative consequences. Identifying adolescents at risk for developing depression would enable the monitoring of risk factors and the development of early intervention strategies. Using machine learning to combine several risk factors from multiple modalities might allow prediction of depression onset at the individual level. Methods: A subsample of a multisite longitudinal study in adolescents, the IMAGEN study, was used to predict future (subthreshold) major depressive disorder onset in healthy adolescents. Based on 2-year and 5-year follow-up data, participants were grouped into the following: 1) those developing a ..

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University of Melbourne Researchers

Grants

Awarded by MQ Brighter Futures Award


Awarded by National Institute of Mental Health of the National Institutes of Health


Awarded by National Health and Medical Research Council (NHMRC) Career Development Fellowship


Awarded by NHMRC Career Development Award


Awarded by European Union


Awarded by ERC


Awarded by Human Brain Project


Awarded by Medical Research Council


Awarded by National Institutes of Health (NIH)


Awarded by Bundesministerium fuer Bildung und Forschung (BMBF)


Awarded by Deutsche Forschungsgemeinschaft (DFG)


Awarded by Medical Research Foundation and Medical Research Council


Awarded by ANR


Awarded by Eranet Neuron


Awarded by Fondation de France


Awarded by Fondation pour la Recherche Medicale


Awarded by Fondation de lAvenir


Awarded by National Institutes of Health, Science Foundation Ireland


Awarded by USA (Axon, Testosterone and Mental Health during Adolescence)


Awarded by NIH Consortium



Funding Acknowledgements

This work was supported by the MQ Brighter Futures Award (MQBFC/2 [to LS] ) , the National Institute of Mental Health of the National Institutes of Health (Award Number R01MH117601 [to LS] ) , a National Health and Medical Research Council (NHMRC) Career Development Fellowship (1140764 [to LS] ) , the Dame Kate Campbell Fellowship from the Faculty of Medicine, Dentistry and Health Sciences at The University of Melbourne, and an NHMRC Career Development Award (141738 [to CGD] ) . This work received support from the following sources: the European Union-funded FP6 Integrated Project IMAGEN (Reinforcement-related behavior in normal brain function and psychopathology) (LSHM-CT-2007-037286) , the Horizon 2020-funded ERC Advanced Grant "STRATIFY" (Brain network based stratification of reinforcement-related disorders) (695313) , Human Brain Project (HBP SGA 2, 785907, and HBP SGA 3, 945539) , the Medical Research Council Grant "c-VEDA" (Consortium on Vulnerability to Externalizing Disorders and Addictions) (MR/N000390/1) , the National Institutes of Health (NIH) (R01DA049238, A decentralized macro and micro gene-by-environment interaction analysis of substance use behavior and its brain biomarkers) , the National Institute for Health Research Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, the Bundesministerium fuer Bildung und Forschung (BMBF Grant Nos. 01GS08152; 01EV0711; Forschungsnetz AERIAL 01EE1406A, 01EE1406B; Forschungsnetz IMAC-Mind 01GL1745B) , the Deutsche Forschungsgemeinschaft (DFG Grant Nos. SM 80/7-2, SFB 940, TRR 265, NE 1383/14-1) , the Medical Research Foundation and Medical Research Council (Grant Nos. MR/R00465X/1 and MR/S020306/1) , and the NIH-funded ENIGMA (Grant Nos. 5U54EB020403-05 and 1R56AG058854-01) . Further support was provided by grants from the ANR (ANR-12-SAMA-0004, AAPG2019 - GeBra) , the Eranet Neuron (AF12-NEUR0008-01 - WM2NA; and ANR-18-NEUR00002-01 - ADORe) , the Fondation de France (00081242) , the Fondation pour la Recherche Medicale (DPA20140629802) , the Mission Interministerielle de Lutte-contre-les-Drogues-et-les-Conduites-Addictives (MILDECA) , the Assistance-Publique-Hppitaux-de-Paris and INSERM (interface grant) , Paris Sud University IDEX 2012, the Fondation de l'Avenir (grant AP-RM-17-013) , the Federation pour la Recherche sur le Cerveau, the National Institutes of Health, Science Foundation Ireland (16/ERCD/3797) , USA (Axon, Testosterone and Mental Health during Adolescence; RO1 MH085772-01A1) , and by NIH Consortium grant U54 EB020403, supported by a cross-NIH alliance that funds Big Data to Knowledge Centres of Excellence. TB served in an advisory or consultancy role for Lundbeck, Medice, Neurim Pharmaceuticals, Oberberg GmbH, Shire. He received conference support or speakers fee by Lilly, Medice, Novartis and Shire. He has been involved in clinical trials conducted by Shire & Viforpharma. He received royalties from Hogrefe, Kohlhammer, CIP Medien, Oxford University Press. The present work is unrelated to the above grants and relationships. LP served in an advisory or consultancy role for Roche and Viforpharm and received speakers fee from Shire. She received royalties from Hogrefe, Kohl-hammer, and Schattauer. The present work is unrelated to the above grants and relationships. All other authors report no biomedical financial interests or po-tential conflicts of interest.